?? ??? ????? ??? ????????? ?? ?????? ????? ?????? ?? ??? ???? ?? ????? ?????.Tadalafil is 14-fold far more powerful for PDE5 than for PDE11A1 and 40-fold much more potent for PDE5 than for PDE11A4, two in the four regarded forms of PDE11. PDE11 can be an enzyme found in human prostate, testes, skeletal muscle and in other tissues. In vitro, tadala